Gene-wide tagging study of the association between

To determine the association between polymorphisms of the multidrug transporter genes , and , and drug resistance in epilepsy by genotyping comprehensive sets of tagging SNPs. A total of 25 tagging SNPs from , and genes were genotyped in a total of 590 Han Chinese epilepsy patients (262 drug resista...

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Published inPharmacogenomics Vol. 12; no. 3; pp. 319 - 325
Main Authors Kwan, Patrick, Wong, Virginia, Ng, Ping Wing, Lui, Colin Hiu Tung, Sin, Ngai Chuen, Wong, Ka Sing, Baum, Larry
Format Journal Article
LanguageEnglish
Published Future Medicine Ltd 01.03.2011
Subjects
antiepileptic drugs
drug resistance
epilepsy
pharmacogenomics
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Summary:To determine the association between polymorphisms of the multidrug transporter genes , and , and drug resistance in epilepsy by genotyping comprehensive sets of tagging SNPs. A total of 25 tagging SNPs from , and genes were genotyped in a total of 590 Han Chinese epilepsy patients (262 drug resistant and 328 drug responsive). Genotype and allele distributions in drug-responsive and drug-resistant patients were compared. Genotype distributions of all the selected SNPs were consistent with Hardy-–Weinberg equilibrium. None of the polymorphisms, either genotype or allele distributions, were significantly associated with drug resistance. For each gene, no haplotypes of over 1% frequency, and that included all SNPs of the gene, were associated with drug resistance. This gene-wide tagging study revealed no association between , and genetic polymorphisms and multidrug resistance in epilepsy. Original submitted 11 August 2010; Revision submitted 5 November 2010.
ISSN:1462-2416
1744-8042
DOI:10.2217/pgs.10.183