Vitamin K epoxide reductase complex 1

• Published in: Pharmacogenomics Vol. 10; no. 6; pp. 1025 - 1032
• Main Authors: Sipeky, Csilla, Csongei, Veronika, Jaromi, Luca, Safrany, Eniko, Polgar, Noemi, Lakner, Lilla, Szabo, Melinda, Takacs, Istvan, Melegh, Bela
• Format: Journal Article
• Language: English
• Published: Future Medicine Ltd 01.06.2009
• Subjects: anticoagulants; haplotype profile; Hungarian; Roma; VKORC1; warfarin
• ISSN: 1462-2416; 1744-8042
• DOI: 10.2217/pgs.09.46

The aim of this work was to determine the haplotype profile in healthy Hungarian and Roma population samples, and to compare our data with other selected populations. Using haplotype tagging SNPs (G-1639A, G9041A and C6009T), we characterized Hungarian (n = 510) and Roma (n = 451) population samples with regard to and haplotypes. In the Hungarian samples, the and haplotypes accounted for 3, 39, 37 and 21%, respectively and by contrast, in the Roma population samples the VKORC1 variants were 5, 30, 46 and 19%, respectively. Comparing the genotypes of Roma and Hungarian populations, difference was found in the (6.87 vs 13.5%), (13.9 vs 19.2%) and (21.9 vs 13.7%) haplotype combinations. Comparing each group with the others, and our data with findings published previously by other groups, the genetic profile in Hungarians was more similar to European Caucasians and Americans with European descent than to Roma samples. Clear differences could be detected between Roma versus Hungarians and European or American Caucasians; the Roma population had only minor similarities with data from India.