Ferucarbotran-loaded red blood cells as long circulating MRI contrast agents: first

The encapsulation of superparamagnetic iron oxide contrast agents in red blood cells (RBCs) could overcome their rapid removal by reticulo-endothelial system improving their stability in blood circulation. Murine ferucarbotran-loaded RBCs were tested as new contrasting agents in MRI application. A s...

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Bibliographic Details
Published inNanomedicine (London, England) Vol. 13; no. 7; pp. 675 - 687
Main Authors Antonelli, Antonella, Pacifico, Severina, Sfara, Carla, Tamma, Marialuisa, Magnani, Mauro
Format Journal Article
LanguageEnglish
Published Future Medicine Ltd 01.05.2018
Subjects
angiography
ferucarbotran
intravascular contrast
MRI
SPIO-loaded RBCs
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Summary:The encapsulation of superparamagnetic iron oxide contrast agents in red blood cells (RBCs) could overcome their rapid removal by reticulo-endothelial system improving their stability in blood circulation. Murine ferucarbotran-loaded RBCs were tested as new contrasting agents in MRI application. A superior visualization of organs and cerebral vessels was evidenced in ferucarbotran-loaded RBCs-treated mice compared with the controls. The signal enhancement lasted for days, while the contrast from bulk ferucarbotran disappeared after few minutes. Ferucarbotran-loaded RBCs showed to improve diagnostic imaging and their use may extend the time frame for MRI and magnetic resonance angiography since to date the time frame for data acquisition has been limited to the first pass.
ISSN:1743-5889
1748-6963
DOI:10.2217/nnm-2017-0339