Incidence of

Prophylaxis against pneumonia (PJP) is currently recommended for patients receiving chemoradiation with temozolomide for newly diagnosed glioblastoma multiforme. At our institution, PJP prophylaxis during temozolomide treatment has not been routinely given because of the paucity of supporting data....

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Published inCNS oncology Vol. 3; no. 4; pp. 267 - 273
Main Authors Neuwelt, Alexander J, Nguyen, Tam M, Fu, Rongwei, Bubalo, Joseph, Tyson, Rose Marie, Lacy, Cynthia, Gahramanov, Seymur, Nasseri, Morad, Barnes, Penelope D, Neuwelt, Edward A
Format Journal Article
LanguageEnglish
Published Future Medicine Ltd 01.07.2014
Subjects
brain radiation
glioblastoma
temozolomide
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Summary:Prophylaxis against pneumonia (PJP) is currently recommended for patients receiving chemoradiation with temozolomide for newly diagnosed glioblastoma multiforme. At our institution, PJP prophylaxis during temozolomide treatment has not been routinely given because of the paucity of supporting data. We investigated the rate of PJP infections in our patients. We conducted a retrospective chart review of 240 brain tumor patients treated between 1999 and 2012 with temozolomide and no PJP prophylaxis, 127 of which received concurrent chemoradiation. One in 240 patients (0.4%; 95% CI: 0.01-2.00; median total dose: 7375 mg/m ; interquartile range: 1300) were diagnosed with PJP. There was a <1% rate of PJP for brain tumor patients treated with temozolomide until progression without PJP prophylaxis.
ISSN:2045-0907
2045-0915
DOI:10.2217/cns.14.24