Biochemical study of the combined effects of endosulfan, dimethoate and carbaryl on albino rats

• Published in: Pesticidi (Beograd) Vol. 16; no. 2
• Main Authors: Selmanoglu-Ozmen, G, Akay, M.T. (Hacettepe University, Beytepe (Turkey). Faculty of Sciences, Department of Biology)
• Format: Journal Article
• Language: English
• Published: 01.04.2001
• Subjects: ACTIVIDAD ENZIMATICA; ACTIVITE ENZYMATIQUE; BLOOD COMPOSITION; CARBARIL; CARBARYL; COMPOSICION DE LA SANGRE; COMPOSITION DU SANG; DIMETHOATE; DIMETOATO; ENDOSULFAN; ENZYMIC ACTIVITY; RAT; RATA; RATS
• ISSN: 0352-9029

The effects of the combinations of three different pesticides: endosulfan, dimethoate and carbaryl on rats were investigated by the determination of serum AST (aspartate aminotransferase), ALT (alanine aminotransferase), ALP (alkaline phosphatase), pseudocholinesterase enzyme activities and biochemical analysis in serum (blood urea nitrogen, uric acid, total protein, albumin, glucose, creatinine and cholesterol). Single, two and three combinations of selected pesticides: endosulfan (6.12 mg/kg/day), dimethoate (20.4 mg/kg/day) and carbaryl (10.1 mg/kg/day) were administered orally to the Wister albino male rats daily for 3.5 months. The obtained results showed that each of the pesticides administered individually caused an increase in ALP enzyme activities of rats. Increase of AST activity and decrease of the pseudocholinesterase activity by single dimethoate treatment were found. Statistically significant increases in AST, ALT, ALP and pseudocholinesterase activities were found in rats treated with the combinations of pesticides, in relation, to the control. Significant changes in some of the serum parameters in rats given single and the combination of pesticides, were found.