Diet effect on activity of product ratios of uric acid, sodium urate, and ammonium in urine formed by healthy Beagles

• Published in: American journal of veterinary research Vol. 56; no. 3
• Main Authors: Bartges, J.W. (University of Georgia, Athens, GA.), Osborne, C.A, Felice, L.J, Allen, T.A, Brown, C, Unger, L.K, Koehler, L.A, Bird, K.A, Chen, M
• Format: Journal Article
• Language: English
• Published: 01.03.1995
• Subjects: ACIDE URIQUE; ACIDO URICO; CARNE; CASEINA; CASEINE; CHIEN; COMPOSE DE L'AMMONIUM; COMPUESTOS DE AMONIO; CONTENIDO PROTEICO; DIETA; ORINA; PATHOGENESE; PATOGENESIS; PERRO; REGIME ALIMENTAIRE; SALES; SEL; TENEUR EN PROTEINES; URINE; UROLITHIASE; UROLITIASIS; VIANDE
• ISSN: 0002-9645; 1943-5681

Urine activity product ratios of uric acid, sodium urate, and ammonium urate and urinary excretion of metabolites were determined in 24-hour samples produced by 6 healthy Beagles during periods of consumption of a low-protein, casein-based diet (diet A) and a high-protein, meat-based diet(diet B). Comparison of effects of diet A with those of diet B revealed: significantly lower activity product ratios of uric acid (P = 0.025), sodium urate (P = 0.045), and ammonium urate (P = 0.0045); significantly lower 24-hour urinary excretion of uric acid (P = 0.002), ammonia (P = 0.0002), sodium (P = 0.01), calcium (P = 0.005), phosphorus (P = 0.0003), magnesium (P = 0.01), and oxalic acid (P = 0.004); significantly (P = 0.0001) higher 24-hour urine pH; and significantly (P = 0.01) lower endogenous creatinine clearance. These results suggest that consumption of diet A minimizes changes in urine that predispose dogs to uric acid, sodium urate, and ammonium urate urolithiasis