MDM2 Associates with Polycomb Repressor Complex 2 and Enhances Stemness-Promoting Chromatin Modifications Independent of p53

• Main Authors: Wienken, Magdalena, Antje DickmannsauthorInstitute of Molecular Oncology, Göttingen Center for Molecular Biosciences (GZMB), University Medical Center Göttingen, Göttingen 37077, Germany, Alice NemajerovaauthorDepartment of Pathology, School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA, Daniela KramerauthorInstitute of Molecular Oncology, Göttingen Center for Molecular Biosciences (GZMB), University Medical Center Göttingen, Göttingen 37077, Germany, Zeynab NajafovaauthorDepartment of General, Visceral, and Pediatric Surgery, University Medical Center Göttingen, Göttingen 37077, Germany, Miriam WeissauthorInstitute of Molecular Oncology, Göttingen Center for Molecular Biosciences (GZMB), University Medical Center Göttingen, Göttingen 37077, Germany, Oleksandra KarpiukauthorInstitute of Molecular Oncology, Göttingen Center for Molecular Biosciences (GZMB), University Medical Center Göttingen, Göttingen 37077, Germany, Moustapha KassemauthorMolecular Endocrinology and Stem Cell Research Unit (KMEB), University Hospital of Odense and University of Southern Denmark, Odense 5000, Denmark, Yanping ZhangauthorDepartment of Radiation Oncology and Lineberger Comprehensive Cancer Center, the University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA, Guillermina LozanoauthorDepartment of Genetics, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA, Steven A. JohnsenauthorDepartment of General, Visceral, and Pediatric Surgery, University Medical Center Göttingen, Göttingen 37077, Germany, Ute M. MollauthorInstitute of Molecular Oncology, Göttingen Center for Molecular Biosciences (GZMB), University Medical Center Göttingen, Göttingen 37077, GermanyDepartment of Pathology, School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA, Xin ZhangauthorInstitute of Molecular Oncology, Göttingen Center for Molecular Biosciences (GZMB), University Medical Center Göttingen, Göttingen 37077, Germany, Matthias DobbelsteinauthorInstitute of Molecular Oncology, Göttingen Center for Molecular Biosciences (GZMB), University Medical Center Göttingen, Göttingen 37077, Germany
• Format: Journal Article
• Language: English
• Published: 2015
• Subjects: cell proliferation; chromatin; fibroblasts; genes; histones; humans; induced pluripotent stem cells; lysine; mice; neoplasm cells; neoplasms; oncogene proteins; ubiquitin-protein ligase; ubiquitination