FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P₁) modulation

• Main Authors: Choi, Ji Woong, Gardell, Shannon E, Herr, Deron R, Rivera, Richard, Lee, Chang-Wook, Noguchi, Kyoko, Teo, Siew Teng, Yung, Yun C, Lu, Melissa, Kennedy, Grace, Chun, Jerold
• Format: Journal Article
• Language: English
• Published: 2015
• Subjects: animal models; astrocytes; encephalitis; in situ hybridization; in vitro studies; mechanism of action; metabolites; mice; mutants; neurons; oral administration; receptors; sclerosis; signal transduction; sphingosine