In vitro effect of ethylenediaminetetraacetic acid-tris on te efficacy of hatchery disinfectants

Solutions of ethylenediaminetetraacetic acid (EDTA)-Tris showed synergistic or additive effects on gram-negative bacteria when combined with hatchery disinfectants consisting of phenol and detergent (Magnaphen-100), quaternary ammonium compound (QAC) and glutaraldehyde (Synergize), QAC (BioSentry 90...

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Bibliographic Details
Published inAvian diseases Vol. 44; no. 4; pp. 901 - 906
Main Authors Wooley, R.E, Sander, J.E, Maurer, J.J, Gibbs, P.S
Format Journal Article
LanguageEnglish
Published 2000
Subjects
antagonism
application rate
detergents
disinfectants
EDTA (chelating agent)
efficacy
evaluation
glutaraldehyde
Gram-negative bacteria
hatcheries
hydrogen peroxide
interactions
mixtures
mortality
phenolic compounds
quaternary ammonium compounds
resistance
synergism
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Summary:Solutions of ethylenediaminetetraacetic acid (EDTA)-Tris showed synergistic or additive effects on gram-negative bacteria when combined with hatchery disinfectants consisting of phenol and detergent (Magnaphen-100), quaternary ammonium compound (QAC) and glutaraldehyde (Synergize), QAC (BioSentry 904), and hydrogen peroxide. The gram-positive bacteria reacted less favorably, with reaction mixtures showing all three levels of potentiation (synergistic, additive, and antagonistic). Combinations of EDTA-Tris and a commercial glutaraldehyde solution (Glutracide), when mixed with the test organisms, showed mostly antagonistic effects. Solutions of EDTA-Tris decreased the concentration of hatchery disinfectants required for bacterial killing by 75% in those situations in which synergistic potentiation occurred. EDTA-Tris is nontoxic to 12-day-old embryos. Serial passage of the test organisms in solutions of EDTA-Tris did not result in the development of resistant forms.
ISSN:0005-2086
1938-4351