Sequence of the goat alpha-lactalbumin-encoding gene: comparison with the bovine gene and evidence of related sequence of the goat genome

The isolation and characterization of a genomic clone encoding goat alpha-lactalbumin (alphaLA) are described, and its sequence was aligned with that of its bovine counterpart. The 5'-flanking regions are highly homologous, but two small insertions were found in the goat sequence. One of these...

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Bibliographic Details
Published inGene Vol. 98; no. 2; pp. 271 - 276
Main Authors Vilotte, J.L, Soulier, S, Printz, C, Mercier, J.C
Format Journal Article
LanguageEnglish
Published 1991
Subjects
amino acid sequences
cattle
cloning
duplication
evolution
exons
genbank/m36393
genes
goats
introns
lactalbumin
molecular sequence data
nucleotide sequences
restriction mapping
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Summary:The isolation and characterization of a genomic clone encoding goat alpha-lactalbumin (alphaLA) are described, and its sequence was aligned with that of its bovine counterpart. The 5'-flanking regions are highly homologous, but two small insertions were found in the goat sequence. One of these insertions fills the gap found in the so-called 'milk-box' consensus sequence of the bovine gene. Southern analysis indicates the presence of several alphaLA-related sequences in the goat genome, as previously observed in cow and sheep, which suggests that the relevant duplication event(s) occurred before divergence of these ruminant species.
ISSN:0378-1119
1879-0038