Metabolism of naphthalene in rooster

1. The metabolism of naphthalene in roosters was similar to that in rats. At least 45% of the dose was isolated from the urine as metabolites that could be formed from arene oxide precursors. 2. Urine was the major route for excretion (79%) of 14C-naphthalene from colostomized roosters. Roosters wit...

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Published inXenobiotica Vol. 18; no. 9; pp. 1057 - 1062
Main Authors Bakke, J.E, Davison, K.L
Format Journal Article
LanguageEnglish
Published 1988
Subjects
chickens
excretion
isotope labeling
metabolism
metabolites
naphthalene
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Abstract 1. The metabolism of naphthalene in roosters was similar to that in rats. At least 45% of the dose was isolated from the urine as metabolites that could be formed from arene oxide precursors. 2. Urine was the major route for excretion (79%) of 14C-naphthalene from colostomized roosters. Roosters with cannulated bile ducts excreted about 24% of the dose in bile. 3. Roosters excreted tetrahydrotrihydroxy mercapturic acids of naphthalene as major urinary metabolites which indicates either the formation of diepoxide intermediates or sequential epoxidation-conjugation processes. 4. The major biliary metabolites in rooster bile were characterized as cysteine and cysteinylglycine conjugates of tetrahydrotrihydroxynaphthalenes.
AbstractList 1. The metabolism of naphthalene in roosters was similar to that in rats. At least 45% of the dose was isolated from the urine as metabolites that could be formed from arene oxide precursors. 2. Urine was the major route for excretion (79%) of 14C-naphthalene from colostomized roosters. Roosters with cannulated bile ducts excreted about 24% of the dose in bile. 3. Roosters excreted tetrahydrotrihydroxy mercapturic acids of naphthalene as major urinary metabolites which indicates either the formation of diepoxide intermediates or sequential epoxidation-conjugation processes. 4. The major biliary metabolites in rooster bile were characterized as cysteine and cysteinylglycine conjugates of tetrahydrotrihydroxynaphthalenes.
Author Bakke, J.E
Davison, K.L
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Snippet 1. The metabolism of naphthalene in roosters was similar to that in rats. At least 45% of the dose was isolated from the urine as metabolites that could be...
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StartPage 1057
SubjectTerms chickens
excretion
isotope labeling
metabolism
metabolites
naphthalene
Title Metabolism of naphthalene in rooster
Volume 18
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