Metabolism of naphthalene in rooster

1. The metabolism of naphthalene in roosters was similar to that in rats. At least 45% of the dose was isolated from the urine as metabolites that could be formed from arene oxide precursors. 2. Urine was the major route for excretion (79%) of 14C-naphthalene from colostomized roosters. Roosters wit...

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Bibliographic Details
Published inXenobiotica Vol. 18; no. 9; pp. 1057 - 1062
Main Authors Bakke, J.E, Davison, K.L
Format Journal Article
LanguageEnglish
Published 1988
Subjects
chickens
excretion
isotope labeling
metabolism
metabolites
naphthalene
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Summary:1. The metabolism of naphthalene in roosters was similar to that in rats. At least 45% of the dose was isolated from the urine as metabolites that could be formed from arene oxide precursors. 2. Urine was the major route for excretion (79%) of 14C-naphthalene from colostomized roosters. Roosters with cannulated bile ducts excreted about 24% of the dose in bile. 3. Roosters excreted tetrahydrotrihydroxy mercapturic acids of naphthalene as major urinary metabolites which indicates either the formation of diepoxide intermediates or sequential epoxidation-conjugation processes. 4. The major biliary metabolites in rooster bile were characterized as cysteine and cysteinylglycine conjugates of tetrahydrotrihydroxynaphthalenes.
ISSN:0049-8254
1366-5928