Explusion of Trichostrongylus colubriformis by high and low responder guinea-pigs

Guinea-pigs with genetically determined susceptibility to infection with Trichostrongylus colubriformis (or low responders) rejected both primary and secondary infections with this parasite more slowly than resistant animals (high responders). Low responders were not protected with a vaccination pro...

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Bibliographic Details
Published inInternational journal for parasitology Vol. 24; no. 4; pp. 527 - 531
Main Authors Rothwell, T.L.W, Wagland, B.M, Sangster, N.C
Format Journal Article
LanguageEnglish
Published 1994
Subjects
guinea pigs
immune response
immunogenetics
infection
line differences
nematode infections
primary infections
secondary infections
Trichostrongylus
Trichostrongylus colubriformis
vaccination
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Summary:Guinea-pigs with genetically determined susceptibility to infection with Trichostrongylus colubriformis (or low responders) rejected both primary and secondary infections with this parasite more slowly than resistant animals (high responders). Low responders were not protected with a vaccination procedure which was highly effective in outbred animals. The relatively poor protective immune responses that develop in low responder guinea-pigs are evocative of the responses of the natural host to infection with this parasite and suggest that low responder guinea-pigs have potential for the study of T. colubriformis protective antigens and for the development of adjuvants to enhance antiparasitic effector responses in vaccinated hosts.
ISSN:0020-7519
1879-0135