RNA folding dynamics: computer simulations by a genetic algorithm

Genetic algorithms exploit principles of natural evolution for optimization procedures. It is shown that RNA folding pathways may be simulated by a genetic algorithm. In addition to improvements of RNA structure predictions, an implementation of genetic algorithm allows one to simulate essential fea...

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Bibliographic Details
Main Authors Gultyaev, A.P, Batenburg, F.H.D. van, Pleij, C.W.A
Format Book
LanguageEnglish
Published Washington, DC (USA) American Chemical Society 1998
Subjects
ARN
MOLECULAR WEIGHT
PESO MOLECULAR
POIDS MOLECULAIRE
RNA
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Summary:Genetic algorithms exploit principles of natural evolution for optimization procedures. It is shown that RNA folding pathways may be simulated by a genetic algorithm. In addition to improvements of RNA structure predictions, an implementation of genetic algorithm allows one to simulate essential features of RNA dynamics, like e.g. the folding of a molecule during its synthesis, pseudoknot formation functional metastable structures and conformational transitions. Thus it is shown that such an approach can also serve as a tool to study RNA dynamics
Bibliography:F30
L10
1997079392
ISBN:0841235414
9780841235410