Effects of clomiphene citrate on ovulation, implantation, fetal growth and chromosomes in mice

Effects of clomiphene citrate (CC) doses 2.5 and 5 microg/gr body weight on ovulation, implantation rate, fetal outcome and chromosomes of 120 female mice were evaluated in this study. No structural and/or numerical chromosomal aberrations and morphological abnormality of the newborn mice were obser...

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Bibliographic Details
Published inTurkish Journal of Medical Sciences (Turkey) Vol. 26
Main Authors Dokmeci, F, Teksen, F, Kurtay, G, Sayli,B.S. (Ankara Univ., Faculty of Medicine, Ankara (Turkey)) Bilgili, A, Izgur, H. (Ankara Univ., Faculty of Veterinary Medicine, Ankara (Turkey))
Format Publication
LanguageEnglish
Published 1996
Subjects
CHROMOSOME
CHROMOSOMES
CITRATE
CITRATES
CITRATOS
CROMOSOMAS
GROWTH RATE
INDICE DE CRECIMIENTO
MICE
OVULACION
OVULATION
RATON
SOURIS
TAUX DE CROISSANCE
TRANSPLANTATION
TRASPLANTES
TURKEY
TURQUIA
TURQUIE
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Summary:Effects of clomiphene citrate (CC) doses 2.5 and 5 microg/gr body weight on ovulation, implantation rate, fetal outcome and chromosomes of 120 female mice were evaluated in this study. No structural and/or numerical chromosomal aberrations and morphological abnormality of the newborn mice were observed in both doses. CC, administered on the mating and the consecutive days completely inhibited the gestation while implantation rates and number of newborns decreased significantly as the dose increased. However we did not observe any adverse effect of CC on fetal growth and development
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