Induction of micronuclei in rat bone marrow after chronic exposure to lead acetate trihydrate

The data concerning the mutagenic, clastogenic and carcinogenic properties of inorganic lead compounds have been conflicting. Here, we evaluated the frequency of micronuclei in bone marrow erythrocytes of male rats treated with lead acetate trihydrate. Outbred male Wistar rats were exposed daily to...

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Published inFolia veterinaria Vol. 50; no. 3
Main Authors Alghazal, M.A, Sutiakova ,I, Kovalkovicova , N, Legath, J, Pistl, J, Falis, M, Sabo, R, Benova, K, Droppova, L, Vaczi, P
Format Journal Article
LanguageEnglish
Published 2006
Subjects
ERITROCITOS
ERYTHROCYTE
ERYTHROCYTES
GENOTOXICIDAD
GENOTOXICITE
GENOTOXICITY
http://www.fao.org/aos/agrovoc#c_2659
http://www.fao.org/aos/agrovoc#c_36150
http://www.fao.org/aos/agrovoc#c_4235
http://www.fao.org/aos/agrovoc#c_4788
http://www.fao.org/aos/agrovoc#c_5260
LEAD
METHODE
METHODS
METODOS
NOYAU CELLULAIRE
NUCLEO
NUCLEUS
PLOMB
PLOMO
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Summary:The data concerning the mutagenic, clastogenic and carcinogenic properties of inorganic lead compounds have been conflicting. Here, we evaluated the frequency of micronuclei in bone marrow erythrocytes of male rats treated with lead acetate trihydrate. Outbred male Wistar rats were exposed daily to dose of 100 mg perl of drinking water for 125 days. The effects of lead acetate trihydrate are both cytotoxic and genotoxic because of a decrease in the ratio of polychromatic to normochromatic erythrocytes and an increase in the frequency of micronucleated polychromatic erythrocytes, respectively.
Bibliography:L50
2006T00559
http://www.uvm.sk/dept/journals/folia.html
ISSN:0015-5748