Major proteolytic pathways in skeletal muscle

Skeletal muscle contains multiple proteolytic systems that are presumably responsible for the breakdown of specific proteins. Three major proteolitic pathways operate in skeletal muscle, although such a simple division is too simplified. The best known proteolytic system is the lysosomal pathway. Ly...

Full description

Saved in:
Bibliographic Details
Published inZbornik Biotehniske fakultete Univerze v Ljubljani (Slovenia) no. 70
Main Authors Cervek, M, Stekar, J.M.A. (Ljubljana Univ. (Slovenia). Biotechnical Fac., Zootechnical Dept.), Attaix, D. (INRA, Theix (France))
Format Journal Article
LanguageSlovenian
Published 1997
Subjects
CATABOLISM
CATABOLISME
CATABOLISMO
LISOZIMA
LYSOZYME
MAMIFEROS
MAMMALS
MAMMIFERE
METABOLISME DES PROTEINES
METABOLISMO PROTEICO
MUSCLE
MUSCLES
MUSCULOS
PROTEIN METABOLISM
PROTEOLISIS
PROTEOLYSE
PROTEOLYSIS
Online AccessGet more information

Cover

More Information
Summary:Skeletal muscle contains multiple proteolytic systems that are presumably responsible for the breakdown of specific proteins. Three major proteolitic pathways operate in skeletal muscle, although such a simple division is too simplified. The best known proteolytic system is the lysosomal pathway. Lysosomes are particularly abundant in liver, and they are not involved in the degradation of myofibrillar proteins. The Ca2+-dependent proteolytic process does not contribute significantly to overall proteolysis in muscles from control and catabolic animals. In fact, there is now growing evidence that calpains do not play a major role in general turnover of intracellular protein, but are involved in limited proteolysis of some specific target proteins. Fagan et al. (1987) demonstrated that skeletal muscle also contains a soluble ATP-ubiquitin-dependent proteolytic system.There is more and more evidence that ATP-ubiqutin-dependent proteolitic system has a key role in muscle protein breakdown.
Bibliography:1998010090
L52
L51
ISSN:1408-3434