The significance of the NO system in the pathogenesis of gastric disorders caused by indomethacin

According to the results obtained it can be concluded that NO-system play important role in gastroprotection, because both endogenous (L-arginine) and exogenous NO-donor (GTN) show anti ulcer activity. Antiulcer effect of GTN is dose dependent and significant, no matter whether drug is applied preve...

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Main Authors Velev, R., Fakultet veterinarske medicine, Skopje (The Former Yugoslav Republic of Macedonia), Cupic, V., Fakultet veterinarske medicine, Beograd (Serbia), Dobric, S., Vojnomedicinska akademija, Beograd (Serbia), Krleska-Veleva, N., Replekfarm AD, Kozle, Skopje (The Former Yugoslav Republic of Macedonia)
Format Conference Proceeding
LanguageSerbian
Published Beograd (Serbia) Srpsko veterinarsko drustvo 2009
Subjects
DIGESTIVE SYSTEM DISEASES
ENFERMEDADES DEL SISTEMA DIGESTIVO
http://www.fao.org/aos/agrovoc#c_16133
http://www.fao.org/aos/agrovoc#c_2276
http://www.fao.org/aos/agrovoc#c_36996
http://www.fao.org/aos/agrovoc#c_6464
INDOMETACIN
INDOMETACINA
INDOMETACINE
MALADIE DE L'APPAREIL DIGESTIF
NITRIC OXIDE
OXIDO NITRICO
OXYDE NITRIQUE
RAT
RATA
RATS
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Abstract According to the results obtained it can be concluded that NO-system play important role in gastroprotection, because both endogenous (L-arginine) and exogenous NO-donor (GTN) show anti ulcer activity. Antiulcer effect of GTN is dose dependent and significant, no matter whether drug is applied preventive or therapeutic. Our results suggest the potential therapeutic use of NO-donors in protection against NSAID-induced ulcerogenesis.
AbstractList According to the results obtained it can be concluded that NO-system play important role in gastroprotection, because both endogenous (L-arginine) and exogenous NO-donor (GTN) show anti ulcer activity. Antiulcer effect of GTN is dose dependent and significant, no matter whether drug is applied preventive or therapeutic. Our results suggest the potential therapeutic use of NO-donors in protection against NSAID-induced ulcerogenesis.
Author Velev, R., Fakultet veterinarske medicine, Skopje (The Former Yugoslav Republic of Macedonia)
Dobric, S., Vojnomedicinska akademija, Beograd (Serbia)
Cupic, V., Fakultet veterinarske medicine, Beograd (Serbia)
Krleska-Veleva, N., Replekfarm AD, Kozle, Skopje (The Former Yugoslav Republic of Macedonia)
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  fullname: Dobric, S., Vojnomedicinska akademija, Beograd (Serbia)
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  fullname: Krleska-Veleva, N., Replekfarm AD, Kozle, Skopje (The Former Yugoslav Republic of Macedonia)
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DocumentTitle_FL Znacaj NO-sistema u patogenezi poremecaja gastricne mukoze uzrokovanih indometacinom
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Snippet According to the results obtained it can be concluded that NO-system play important role in gastroprotection, because both endogenous (L-arginine) and...
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StartPage 403
SubjectTerms DIGESTIVE SYSTEM DISEASES
ENFERMEDADES DEL SISTEMA DIGESTIVO
http://www.fao.org/aos/agrovoc#c_16133
http://www.fao.org/aos/agrovoc#c_2276
http://www.fao.org/aos/agrovoc#c_36996
http://www.fao.org/aos/agrovoc#c_6464
INDOMETACIN
INDOMETACINA
INDOMETACINE
MALADIE DE L'APPAREIL DIGESTIF
NITRIC OXIDE
OXIDO NITRICO
OXYDE NITRIQUE
RAT
RATA
RATS
Title The significance of the NO system in the pathogenesis of gastric disorders caused by indomethacin
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