The significance of the NO system in the pathogenesis of gastric disorders caused by indomethacin

According to the results obtained it can be concluded that NO-system play important role in gastroprotection, because both endogenous (L-arginine) and exogenous NO-donor (GTN) show anti ulcer activity. Antiulcer effect of GTN is dose dependent and significant, no matter whether drug is applied preve...

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Bibliographic Details
Main Authors Velev, R., Fakultet veterinarske medicine, Skopje (The Former Yugoslav Republic of Macedonia), Cupic, V., Fakultet veterinarske medicine, Beograd (Serbia), Dobric, S., Vojnomedicinska akademija, Beograd (Serbia), Krleska-Veleva, N., Replekfarm AD, Kozle, Skopje (The Former Yugoslav Republic of Macedonia)
Format Conference Proceeding
LanguageSerbian
Published Beograd (Serbia) Srpsko veterinarsko drustvo 2009
Subjects
DIGESTIVE SYSTEM DISEASES
ENFERMEDADES DEL SISTEMA DIGESTIVO
http://www.fao.org/aos/agrovoc#c_16133
http://www.fao.org/aos/agrovoc#c_2276
http://www.fao.org/aos/agrovoc#c_36996
http://www.fao.org/aos/agrovoc#c_6464
INDOMETACIN
INDOMETACINA
INDOMETACINE
MALADIE DE L'APPAREIL DIGESTIF
NITRIC OXIDE
OXIDO NITRICO
OXYDE NITRIQUE
RAT
RATA
RATS
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Summary:According to the results obtained it can be concluded that NO-system play important role in gastroprotection, because both endogenous (L-arginine) and exogenous NO-donor (GTN) show anti ulcer activity. Antiulcer effect of GTN is dose dependent and significant, no matter whether drug is applied preventive or therapeutic. Our results suggest the potential therapeutic use of NO-donors in protection against NSAID-induced ulcerogenesis.
Bibliography:COBISS.SR-ID 169318924
978-86-83115-13-6
L70
ISBN:9788683115136
8683115135