Immunobiology of monoclonal antibodies against crude capsular antigen of Pasteurella multocida, Group B

Three monoclonal antibodies (Mabs) directed against crude capsular antigen (CCA) of Pasteurella multocida group B were partially characterized by their immunological properties. Mab C690 and Mab712 were composed of two IgG subclasses namely: IGg and IgG2a. Mab C505 was identified as IgG1. Mab C690 a...

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Bibliographic Details
Published inPhilippine Journal of Biotechnology Vol. 5
Main Authors Gibas C.F.C, Limcumpao J.A, Maslog F.S
Format Journal Article
LanguageEnglish
Published 1994
Subjects
anticorps monoclonal
anticuerpos monoclonales
antigene
antigenos
antigens
immune serum
immunserum
monoclonal antibodies
pasteurella multocida
suero inmune
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Summary:Three monoclonal antibodies (Mabs) directed against crude capsular antigen (CCA) of Pasteurella multocida group B were partially characterized by their immunological properties. Mab C690 and Mab712 were composed of two IgG subclasses namely: IGg and IgG2a. Mab C505 was identified as IgG1. Mab C690 and C712 were found to be agglutinating while C505 was non-agglutinating. All three Mabs were found to promote complement-mediated immune bacteriolysis in vitro as well as in vivo. The use of varying titers of complement and Mabs demonstrated that bacterial activity was due to an antibody-complement complex. Immune serum from rabbits directed against CCA and P. multocida group B showed similar bacterial activity as the Mabs.
Bibliography:L70
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ISSN:0117-0903