Regulation of MDA5-MAVS Antiviral Signaling Axis by TRIM25 through TRAF6-Mediated NF-kB Activation

Tripartite motif protein 25 (TRIM25), mediates K63-linked polyubiquitination of Retinoic acid inducible gene I (RIG-I) that is crucial for downstream antiviral interferon signaling. Here, we demonstrate that TRIM25 is required for melanoma differentiation-associated gene 5 (MDA5) and MAVS mediated a...

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Published inMolecules and cells Vol. 38; no. 9
Main Authors Lee, N.R., Kyung Hee University, Seoul, Republic of Korea, Kim, H.I., Kyung Hee University, Seoul, Republic of Korea, Choi, M.S., Kyung Hee University, Seoul, Republic of Korea, Yi, C.M., Kyung Hee University, Seoul, Republic of Korea, Inn, K.S., Kyung Hee University, Seoul, Republic of Korea
Format Journal Article
LanguageEnglish
Published 01.09.2015
Subjects
CELLS
CELLULE
CELULAS
MAVS,MDA5,NF-kB,TRAF6,TRIM25
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Summary:Tripartite motif protein 25 (TRIM25), mediates K63-linked polyubiquitination of Retinoic acid inducible gene I (RIG-I) that is crucial for downstream antiviral interferon signaling. Here, we demonstrate that TRIM25 is required for melanoma differentiation-associated gene 5 (MDA5) and MAVS mediated activation of NF-kB and interferon production. TRIM25 is required for the full activation of NF-kB at the downstream of MAVS, while it is not involved in IRF3 nuclear translocation. Mechanical studies showed that TRIM25 is involved in TRAF6-mediated NF-kB activation. These collectively indicate that TRIM25 plays an additional role in RIG-I/MDA5 signaling other than RIG-I ubiquitination via activation of NF-kB.
Bibliography:A50
ISSN:1016-8478