Characteristics and Applications of Bioactive Peptides in Skin Care

Bioactive peptides (BAP) showed excellent cosmetic activity than bio-materials such as caffeic acid (CA), gallic acid (GA), and nicotinic acid (NA). Caffeoyl tripeptide-1 (CT-1) is a BAP that is stabilized with Gly-His-Lys (GHK) tripeptide and CA by using Fmoc solid phase peptide synthesis. Digalloy...

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Published inKorean Society for Biotechnology and Bioengineering Journal Vol. 26; no. 6
Main Authors Moh, S.H., Anti-aging Research Institute of BIO-FDnC Co., Ltd., Incheon, Republic of Korea, Jung, D.H., Anti-aging Research Institute of BIO-FDnC Co., Ltd., Incheon, Republic of Korea, Kim, H.S., Anti-aging Research Institute of BIO-FDnC Co., Ltd., Incheon, Republic of Korea, Cho, M.J., Anti-aging Research Institute of BIO-FDnC Co., Ltd., Incheon, Republic of Korea, Seo, H.H., Anti-aging Research Institute of BIO-FDnC Co., Ltd., Incheon, Republic of Korea, Kim, S.J., Sookmyung Womens University, Seoul, Republic of Korea
Format Journal Article
LanguageKorean
Published 01.11.2011
Subjects
ANTIOXIDANTES
ANTIOXIDANTS
ANTIOXYDANT
Bioactive Peptide
Cosmetic
PEPTIDE
PEPTIDES
PEPTIDOS
Skin Care
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Summary:Bioactive peptides (BAP) showed excellent cosmetic activity than bio-materials such as caffeic acid (CA), gallic acid (GA), and nicotinic acid (NA). Caffeoyl tripeptide-1 (CT-1) is a BAP that is stabilized with Gly-His-Lys (GHK) tripeptide and CA by using Fmoc solid phase peptide synthesis. Digalloyl tetrapeptide-19 (DT-19) is stabilized by combining Lys-Glu-Cys-Gly with GA and nicotinoyl tripeptide-1 (NT-1) is synthesized by GHK and NA. According to experiments, CT-1 has an excellent anti-oxidant function even with a very small amount of 10 ppm CT-1. DT-19's tyrosinase inhibition activity has the better effect of about 28.57% in 0.01% and 33.33% in 0.005% of concentration and about 7.89% in 0.001% concentration than vitamin-C. In addition, NT-1 is safer than the NA. Almost BAPs like pal-KTTKS, acetyl hexapeptide, and copper tripeptide-1 have the anti-wrinkle effect while DT-19 and NT-1 are applicable for potential BAPs focused on the whitening effect. The three kinds of BAPs like CT-1, DT-19, and NT-1 consisting of amino acids are safe to the skin, and have more excellent stability than bio-materials which are found to be unstable and cause skin irritation. Due to the high biological activity of BAP in the field of skin care, its utilization will increase constantly.
Bibliography:E21
2012004356
ISSN:1225-7117