FPTase Inhibition Effect of Protostanes from Alismatis Rhizoma and Derivatives from Alisol B 23-acetate

The purpose of this research is to study of inhibitory activity of protostane type triterpens against farnesyl-protein transferase (FPTase). The ingredients of Alismatis Rhizoma, alisol B 23-acetate, C 23-acetate, alisols B and A 24-acetate, and thirteen synthetic analogues from alisol B 23-acetate...

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Published inKorean Journal of Pharmacognosy Vol. 42; no. 3
Main Authors Lee, S.M., Korea Ginseng Corporation Central Research Institute, Daejeon, Republic of Korea, Kwon, B.M., Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea, Min, B.S., Catholic University of Daegu, Gyungsan, Republic of Korea
Format Journal Article
LanguageKorean
Published 01.09.2011
Subjects
Alismatis Rhizoma
Alisol
DRUG PLANTS
Farnesyl-protein transferase
PLANTAS MEDICINALES
PLANTE MEDICINALE
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Summary:The purpose of this research is to study of inhibitory activity of protostane type triterpens against farnesyl-protein transferase (FPTase). The ingredients of Alismatis Rhizoma, alisol B 23-acetate, C 23-acetate, alisols B and A 24-acetate, and thirteen synthetic analogues from alisol B 23-acetate exhibited inhibition activity against FPTase by scintillation proximity assay method. As a result, alisol C 23-acetate, one of the constituents of Alismatis Rhizoma, the synthetic analogues carboxylated and hydroxylated on branch chain of protostane exhibited a significant inhibitory activity. However, the compounds significantly lowered the inhibitory activity, when there is no 3 position keto on protostane skeletone.
Bibliography:F60
2012002093
ISSN:0253-3073