Effect of Docosahexaenoic Acid (DHA) on the Apoptosis of Human Endothelial ECV304 Cells

DHA, one of w-3 fatty acids, modulates cell growth or death though the changes of apoptotic signaling in human endothelial ECV304 cells. We investigated the effects of DHA on the changes of apoptotic signaling in human vascular endothelial ECV304 cells using lipid peroxidation (LPO) metabolites. LPO...

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Published inHanʼguk yongyang hakhoe chi Vol. 39; no. 4
Main Authors Kim, Y.Y. (Sungshin Women's University, Seoul, Republic of Korea), Kim, H.S. (Sungshin Women's University, Seoul, Republic of Korea), Kim, M.H. (Sungshin Women's University, Seoul, Republic of Korea), Jang, S.J. (Sungshin Women's University, Seoul, Republic of Korea), Lee, M.S. (Sungshin Women's University, Seoul, Republic of Korea), E-mail: mlee@sungshin.ac.kr
Format Journal Article
LanguageKorean
Published 01.06.2006
Subjects
ACIDE ARACHIDONIQUE
ACIDE DOCOSAHEXAENOIQUE
ACIDE LINOLEIQUE
ACIDO ARAQUIDONICO
ACIDO DOCOSAHEXAENOICO
ACIDO LINOLEICO
APOPTOSE
APOPTOSIS
ARACHIDONIC ACID
caspase-3
DOCOSAHEXAENOIC ACID
human endothelial ECV304 cells
LINOLEIC ACID
mitochondrial damage
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Summary:DHA, one of w-3 fatty acids, modulates cell growth or death though the changes of apoptotic signaling in human endothelial ECV304 cells. We investigated the effects of DHA on the changes of apoptotic signaling in human vascular endothelial ECV304 cells using lipid peroxidation (LPO) metabolites. LPO could be originated by dietary polyunsaturated fatty acids such as linoleic acid (LA), arachidonic acid (AA) and docosahexaenoic acid (DHA). DHA caused cell death of ECV304 cells compared to LA, AA or control as evidenced by changes in cell morphology and MTT assay.
Bibliography:S20
2007000711
ISSN:0367-6463