Induction of Apoptosis by Immature Prunus salicina Lindl. cv. Soldam

Apoptosis of Prunus salicina Lindl. cv. Soldam, which possesses hematopoiesis, osteoporosis prevention, and antimutagenic effects, at different growth stages was evaluated. Cytotoxic effect of acetone extracts of immature fruits against various tumor cell lines was higher than that of mature fruits,...

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Published inKorean Journal of Food Science and Technology Vol. 37; no. 2
Main Authors Yu, M.H. (Keimyung University, Daegu, Republic of Korea), Im, H.G. (Keimyung University, Daegu, Republic of Korea), Hwang Bo, M.H. (Keimyung University, Daegu, Republic of Korea), Lee, J.W. (Keimyung University, Daegu, Republic of Korea), Lee, I.S. (Keimyung University, Daegu, Republic of Korea), E-mail: inseon@kmu.ac.kr
Format Journal Article
LanguageKorean
Published 01.04.2005
Subjects
APOPTOSE
APOPTOSIS
human breast cancer
Prunus salicina Lindl. cv. Soldam
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Summary:Apoptosis of Prunus salicina Lindl. cv. Soldam, which possesses hematopoiesis, osteoporosis prevention, and antimutagenic effects, at different growth stages was evaluated. Cytotoxic effect of acetone extracts of immature fruits against various tumor cell lines was higher than that of mature fruits, particularly in hormone-independent human breast cancer, MDA-MB-231 cell line. Immature fruit extract increased expression level of pro-apoptotic protein Bax and reduced that of anti-apoptotic protein Bcl-2, and stimulated caspase-3 activity in MDA-MB-231 cells.
Bibliography:2006014547
Q01
ISSN:0367-6293