Effect of Physostigmine and Procyclidine, as a Combinational Prophylactic Regimen for Organophosphate Poisoning on Learning and Memory Process in Rats

• Published in: The Korean Journal of Laboratory Animal Science Vol. 20; no. 4
• Main Authors: Cho, S.O. (Chungbuk National University, Cheongju, Republic of Korea), Park, W.K. (Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea), Cho, Y. (Agency for Defense Development, Daejeon, Republic of Korea), Lee, S.A. (Chungbuk National University, Cheongju, Republic of Korea), Kim, H.K. (Chungbuk National University, Cheongju, Republic of Korea), Kim, Y.B. (Chungbuk National University, Cheongju, Republic of Korea), Seong, Y.H. (Chungbuk National University, Cheongju, Republic of Korea), E-mail: vepharm@chungbuk.ac.kr, Hur, G.H. (Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea), Cheon, K.C. (Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea), Kim, W.S. (Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea), Ha, Y.C. (Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea), Yeon, G.B. (Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea), Kim, J.C. (Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea)
• Format: Journal Article
• Language: Korean
• Published: 01.12.2004
• Subjects: CAPACIDAD MENTAL; CAPACITE MENTALE; MEDICAMENT NEUROTROPE; MEDICAMENTOS NEUROTROPICOS; MENTAL ABILITY; Morris water maze; NEUROTROPIC DRUGS; passive avoidance; procyclidine

The effects of physostigmine and procyclidine, as a combinational prophylactic regimen for organophosphate poisoning, on learning and memory process were exaministering subcutaneously. Procyclidine at doses of 3 through 10 mg/kg produced significant impairment of learning and memory process in step-...