Effect of Physostigmine and Procyclidine, as a Combinational Prophylactic Regimen for Organophosphate Poisoning on Learning and Memory Process in Rats

The effects of physostigmine and procyclidine, as a combinational prophylactic regimen for organophosphate poisoning, on learning and memory process were exaministering subcutaneously. Procyclidine at doses of 3 through 10 mg/kg produced significant impairment of learning and memory process in step-...

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Published inThe Korean Journal of Laboratory Animal Science Vol. 20; no. 4
Main Authors Cho, S.O. (Chungbuk National University, Cheongju, Republic of Korea), Park, W.K. (Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea), Cho, Y. (Agency for Defense Development, Daejeon, Republic of Korea), Lee, S.A. (Chungbuk National University, Cheongju, Republic of Korea), Kim, H.K. (Chungbuk National University, Cheongju, Republic of Korea), Kim, Y.B. (Chungbuk National University, Cheongju, Republic of Korea), Seong, Y.H. (Chungbuk National University, Cheongju, Republic of Korea), E-mail: vepharm@chungbuk.ac.kr, Hur, G.H. (Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea), Cheon, K.C. (Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea), Kim, W.S. (Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea), Ha, Y.C. (Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea), Yeon, G.B. (Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea), Kim, J.C. (Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea)
Format Journal Article
LanguageKorean
Published 01.12.2004
Subjects
CAPACIDAD MENTAL
CAPACITE MENTALE
MEDICAMENT NEUROTROPE
MEDICAMENTOS NEUROTROPICOS
MENTAL ABILITY
Morris water maze
NEUROTROPIC DRUGS
passive avoidance
procyclidine
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Summary:The effects of physostigmine and procyclidine, as a combinational prophylactic regimen for organophosphate poisoning, on learning and memory process were exaministering subcutaneously. Procyclidine at doses of 3 through 10 mg/kg produced significant impairment of learning and memory process in step-through passive avoidance test. However, this harmful effect of procyclidine (3 and 5 mg/kg) was reversed by simultaneous injection of physostigmine (0.1 mg/kg). Procyclidine at dises of 7 and 10 mg/kg produced reversible inhibition of learning and momory process in Morris water maze test.
Bibliography:2005012277
L50
ISSN:1225-813X