Safety Evaluation of Tobacco Substitute (Herbrette); Inhalation Toxicity, Mutagenicity and Immunotoxicity

Inhalation toxicity, mutagenicity, and immunotoxicity tests were performed using a smoke generation system to investigate the safety of Herbrette, a tobacco substitute made with the leaves of Perilla frutescens. ICR mice were exposed to nicotine-free Herbrette smoke with concentrations of 0 (control...

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Published inJournal of toxicology and public health Vol. 20; no. 4
Main Authors Song, K.S. (Seoul National University, Seoul, Republic of Korea), Yoo, G.Y. (3G CARE, Seoul, Republic of Korea), Park, K.H. (Seoul National University, Seoul, Republic of Korea), Song, S.O. (Seoul National University, Seoul, Republic of Korea), Kim, H.W. (Seoul National University, Seoul, Republic of Korea), Kim, J.S. (Seoul National University, Seoul, Republic of Korea), Park, J.H. (Seoul National University, Seoul, Republic of Korea), Eu, G.J. (Seoul National University, Seoul, Republic of Korea), Hua, J. (Seoul National University, Seoul, Republic of Korea), Cho, H.S. (Seoul National University, Seoul, Republic of Korea), Hwang, S.K. (Seoul National University, Seoul, Republic of Korea), Chang, S.H. (Seoul National University, Seoul, Republic of Korea), Tehrani, Arash Minai (Seoul National University, Seoul, Republic of Korea), Yu, K.N. (Seoul National University, Seoul, Republic of Korea), Chae, C.H. (Seoul National University, Seoul, Republic of Korea), Cho, M.H. (Seoul National University, Seoul, Republic of Korea), E-mail: mchotox@snu.ac.kr
Format Journal Article
LanguageEnglish
Published 01.12.2004
Subjects
Herbrette
Immunotoxicity
Inhalation toxicity
MUTAGENICIDAD
MUTAGENICITE
MUTAGENICITY
TABAC
TABACO
TOBACCO
Tobacco substitute
TOXICIDAD
TOXICITE
TOXICITY
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Summary:Inhalation toxicity, mutagenicity, and immunotoxicity tests were performed using a smoke generation system to investigate the safety of Herbrette, a tobacco substitute made with the leaves of Perilla frutescens. ICR mice were exposed to nicotine-free Herbrette smoke with concentrations of 0 (control), 4.08±1.32 mg/㎥ (low dose), 7.72±2.14 mg/㎥ (medium dose) and 12.83±1.69 mg/㎥ (high dose) total particulate matters (TPM) for 4 weeks. When compared to the control group, the body weights, organ weights in the exposed groups did not show any significant differences.
Bibliography:T10
2005011054
ISSN:1226-8399