Phenylpropanoids from Myristica fragrans Houtt

• Published in: Hanʼguk Ŭngyong Saengmyŏng Hwahakhoe chi Vol. 47; no. 3
• Main Authors: Song, M.C. (Kyung Hee University, Suwon, Republic of Korea), Kwon, B.M. (Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea), Ahn, E.M. (Kyung Hee University, Suwon, Republic of Korea), Bang, M.H. (Kyung Hee University, Suwon, Republic of Korea), Kim, S.Y. (Kyung Hee University, Suwon, Republic of Korea), Rho, Y.D. (Kyung Hee University, Suwon, Republic of Korea), Baek, N.I. (Kyung Hee University, Suwon, Republic of Korea), E-mail: nibaek@khu.ac.kr, Lee, H.S. (Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea)
• Format: Journal Article
• Language: Korean
• Published: 01.09.2004
• Subjects: ACAT; CHITIN; chitin synthase; CHITINE; HMG-CoA reductase; meso-dihydroguaiaretic acid; MYRISTICA FRAGRANS; Myristica fragrans Houtt; nectandrin B; OXIDOREDUCTASES; OXIDORREDUCTASAS; OXYDOREDUCTASE; QUITINA; syringin methyl ether
• ISSN: 1738-2203

Myristica fragrans Houtt were extracted in 80% aq. MeOH and solvent fractionated using CHCl₃, EtOAc, n-BuOH and water, successively. The n-BuOH fraction gave three phenylpropanoids through application of silica gel column chromatographies. The chemical structures of the phenylpropanoids were determined by the interpretation of several spectral data, including NMR and MS as meso-dihydroguaiaretic acid (1), nectandrin B (2) and syringin methyl ether (3). Compound 1, which was first isolated from this plant by authors, showed inhibitory activities with 60.0±2.1% (100 μg/ml), 42.6±0.9% (140 μg/ml) and 12.2±0.2% (200 μg/ml) on ACAT(acyl-CoA:Cholesterol Acyltransferase), chitin synthase Ⅲ and HMG-CoA reductase (3-hydroxy-3-methylglutaryl coenzyme A reductase), respectively.