Conservation of Salmonella infection mechanisms in plants and animals

Salmonella virulence in animals depends on effectors injected by Type III Secretion Systems (T3SSs). In this report we demonstrate that Salmonella mutants that are unable to deliver effectors are also compromised in infection of Arabidopsis thaliana plants. Transcriptome analysis revealed that in co...

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Main Authors Schikora , Adam (INRA , Evry (France). UMR 1165 Génomique Végétale), Virlogeux-Payant , Isabelle (INRA , Nouzilly (France). UR 1282 Infectiologie Animale et Santé Publique), Bueso , Edouardo (INRA , Evry (France). UMR 1165 Génomique Végétale), Garcia , Anna Victoria (INRA , Evry (France). UMR 1165 Génomique Végétale), Nilau , Theodora (University of Vienna, Vienne(Autriche). Max F. Perutz Laboratories), Charrier , Amélie (INRA , Evry (France). UMR 1165 Génomique Végétale), Pelletier , Sandra (INRA , Evry (France). UMR 1165 Génomique Végétale), Menanteau , Pierrette (INRA , Nouzilly (France). UR 1282 Infectiologie Animale et Santé Publique), Baccarini , Manuela (University of Vienna, Vienne(Autriche). Max F. Perutz Laboratories), Velge , Philippe (INRA , Nouzilly (France). UR 1282 Infectiologie Animale et Santé Publique), Hirt , Heribert (INRA , Evry (France). UMR 1165 Génomique Végétale)
Format Publication
LanguageEnglish
Published 2011
Subjects
animal
arabidopsis
arabidopsis-thaliana
bactérie
enterica
escherichia-coli o157-h7
innate immunity
listeria-monocytogenes
mutant
mécanisme d'infection
pathogenicity island-2
plante
protein
pseudomonas-syringae
pv. tomato dc3000
salmonella
souris
T3SS
virulence
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Summary:Salmonella virulence in animals depends on effectors injected by Type III Secretion Systems (T3SSs). In this report we demonstrate that Salmonella mutants that are unable to deliver effectors are also compromised in infection of Arabidopsis thaliana plants. Transcriptome analysis revealed that in contrast to wild type bacteria, T3SS mutants of Salmonella are compromised in suppressing highly conserved Arabidopsis genes that play a prominent role during Salmonella infection of animals. We also found that Salmonella originating from infected plants are equally virulent for human cells and mice. These results indicate a high degree of conservation in the defense and infection mechanism of animal and plant hosts during Salmonella infection.
Bibliography:http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=INRA&SrcApp=INRA&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000294689200021
2011045454
10.1371/journal.pone.0024112
http://www.ncbi.nlm.nih.gov/pubmed?term=21915285