A fast algorithm for estimating transmission probabilities in QTL detection designs with dense maps

Background: In the case of an autosomal locus, four transmission events from the parents to progeny are possible, specified by the grand parental origin of the alleles inherited by this individual. Computing the probabilities of these transmission events is essential to perform QTL detection methods...

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Published inhttp://www.gsejournal.org
Main Authors Elsen , Jean Michel(auteur de correspondance) (INRA , Auzeville (France). UR 0631 Station d'Amélioration Génétique des Animaux), Filangi , Olivier (INRA , Rennes (France). UMR 0598 Génétique Animale), Gilbert , Hélène (INRA , Jouy-En-Josas (France). UMR 1313 Génétique Animale et Biologie Intégrative), Le Roy , Pascale (INRA , Rennes (France). UMR 0598 Génétique Animale), Moreno , Carole (INRA , Auzeville (France). UR 0631 Station d'Amélioration Génétique des Animaux)
Format Publication
LanguageEnglish
Published 2009
Subjects
dense map
estimation
fast algorithm
probabilité
qtl
transmission
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Summary:Background: In the case of an autosomal locus, four transmission events from the parents to progeny are possible, specified by the grand parental origin of the alleles inherited by this individual. Computing the probabilities of these transmission events is essential to perform QTL detection methods. [br/]Results: A fast algorithm for the estimation of these probabilities conditional to parental phases has been developed. It is adapted to classical QTL detection designs applied to outbred populations, in particular to designs composed of half and/or full sib families. It assumes the absence of interference. [br/]Conclusion: The theory is fully developed and an example is given.
Bibliography:2009026656
http://www.gsejournal.org/content/41/1/50
10.1186/1297-9686-41-50