Effects of infections bursal disease vaccination strains on the immune system of Leghorn chickens

• Published in: Acta veterinaria Brno Vol. 73; no. 2
• Main Authors: Kulikova, L.(Veterinarni a Farmaceuticka Univ., Brno (Czech Republic). Klinika Chorob Ptaku, Plazu a Drobnych Savcu)E-mail:KulikovaL@vfu.cz, Jurajda, V.(Veterinarni a Farmaceuticka Univ., Brno (Czech Republic). Klinika Chorob Ptaku, Plazu a Drobnych Savcu), Juranova, R.(Veterinarni a Farmaceuticka Univ., Brno (Czech Republic). Klinika Chorob Ptaku, Plazu a Drobnych Savcu)
• Format: Journal Article
• Language: English
• Subjects: ANTIBODIES; ANTICORPS; ANTICUERPOS; BOLSA DE FABRICIO; BOURSE DE FABRICIUS; BURSA FABRICII; CHICKENS; ELISA; ENFERMEDAD DE GUMBORO; GUMBORO DISEASE; MALADIE DE GUMBORO; POLLO; POULET; TEST ELISA; VACCIN; VACCINATION; VACCINES; VACUNA; VACUNACION
• ISSN: 0001-7213

In the present study, levels of post-vaccination antibodies against infectious bursal disease were monitored by the ELISA test in seven experiments with Leghorn chickens free of maternal antibodies. The chickens were vaccinated with commercial vaccines made of viruses of different virulence (A, B, C - mild; D - intermediate; E, F, G - highly virulent). Of the mild vaccines, only vaccine A produced a sufficiently high antibody titre and 100% positivity in the group. Vaccine C, on the other hand, caused a statistically significant atrophy of the bursa Fabricii. The vaccine D produced only 80% positivity, with the lowest average post-vaccination antibodies titres and statistically insignificant bursa Fabricii index. The most virulent vaccines E and F demonstrated an almost 100% positivity, high post-vaccination antibodies titres and statistically significant (P less than 0.01) bursal atrophy. Vaccine G also produced 100% positivity, but caused no damage to the bursa Fabricii. The results of the study point to differences in virulence and immunogenic properties of different vaccination strains.