Mutagenic activity of substances of plant origin

Mutagenic activities of substances of plant origin (extract Angelicae archangelica - alpha-angelicalactone, juglone, extract Humuli lupuli - emodine, hype-ricine, and psoralene) were tested with the aid of the Ames test in the prokaryotic model and low doses [approximating 0,1 LD(50)] and the micron...

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Published inPotravinarske Vedy - UZPI (Czech Republic) Vol. 15; no. 4
Main Authors Turek, B, Kovacova, E, Sestakova, H. (Statni Zdravotni Ustav, Prague (Czech Republic)), Barta, I, Smerak, P, Sedmikova, M
Format Journal Article
LanguageCzech
Published 01.08.1997
Subjects
ANGELICA ARCHANGELICA
APPLICATION RATES
CARCINOGENOS
CARCINOGENS
DOSE D'APPLICATION
DOSIS DE APLICACION
ENSAYO
EXTRACTOS VEGETALES
EXTRAIT D'ORIGINE VEGETALE
HUMULUS LUPULUS
MICOTOXINAS
MUTAGENE
MUTAGENICIDAD
MUTAGENICITE
MUTAGENICITY
MUTAGENOS
MUTAGENS
MYCOTOXINE
MYCOTOXINS
PLANT EXTRACTS
SALMONELLA TYPHIMURIUM
SUBSTANCE CANCERIGENE
TESTAGE
TESTING
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Summary:Mutagenic activities of substances of plant origin (extract Angelicae archangelica - alpha-angelicalactone, juglone, extract Humuli lupuli - emodine, hype-ricine, and psoralene) were tested with the aid of the Ames test in the prokaryotic model and low doses [approximating 0,1 LD(50)] and the micronucleus test on the eukaryotic model. In the Ames test the mutagenic effect has been found only in juglone and alpha-angelicalactone. In the micronucleus test a statistically significant higher freguency of micronuclei in comparison with controls has been found in all substances except angelicalactone namely in at least one of the concentration tested. The resulting effect of tinctures and extracts may differ according to the proportion of certain substances influencing genotoxicity which pass into these solutions. The results of the follow-up of these natural substances show that in many plants used as vegetables, spices, or medicinal herbs, it is possible to anticipate the presence of substances showing mutagenic activity in conditions in vivo and in vitro.
Bibliography:F60
Q03
1997000926
ISSN:0862-8653