Quinolizidines alkaloids: Petrosin and xestospongins from the sponge Oceanapia sp

A bisquinolizidine alkaloid, petrosin (1) and a series of bis-1-oxaquinolizidine, xestospongins (2–9), were obtained from the ethyl acetate extract of the sponge Oceanapia sp. Petrosin was obtained along with xestospongin- C, D, E, F, G, H, I and J having di-hetro atom rings, from the ethyl acetate...

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Bibliographic Details
Main Authors Singh, K.S, Das, B, Naik, C.G
Format Journal Article
LanguageEnglish
Published Indian Academy of Sciences 2011
Subjects
alkaloids
Oceanapia sp
sponges
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Summary:A bisquinolizidine alkaloid, petrosin (1) and a series of bis-1-oxaquinolizidine, xestospongins (2–9), were obtained from the ethyl acetate extract of the sponge Oceanapia sp. Petrosin was obtained along with xestospongin- C, D, E, F, G, H, I and J having di-hetro atom rings, from the ethyl acetate extract of the sponge. The compounds exhibited moderate to high activities against some microorganisms and clinical isolates. The structures of the alkaloids were elucidated by NMR and ESIMS spectroscopic data. The structure of petrosin was confirmed by an X-ray diffraction study.
Bibliography:Journal of Chemical Sciences, vol.123(5); 2011; 601-607