Evaluation of Some Lectins as Anti-protozoal Agents

Ten lectins from different sources were screened for cytotoxic activity against Acanthamoeba sp. (a keratitis-causing amoeba) and Tetrahymena pyriformis (a ciliate). Lectins from Schefflera odorata ("lima-lima" plant) [molecular weight = 271 kDa], Swietenia macrophylla (large leaf mahogany...

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Main Authors Marla A. Endriga, Elmer-Rico E. Mojica, Florinia E. Merca, Marivic S. Lacsamana, Custer C. Deocaris
Format Publication
LanguageEnglish
Published Asian Network for Scientific Information, Pakistan 2005
Subjects
Acanthamoeba sp
cytotoxic
lectins
protozoans
terahymena pyriformis
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Summary:Ten lectins from different sources were screened for cytotoxic activity against Acanthamoeba sp. (a keratitis-causing amoeba) and Tetrahymena pyriformis (a ciliate). Lectins from Schefflera odorata ("lima-lima" plant) [molecular weight = 271 kDa], Swietenia macrophylla (large leaf mahogany) [molecular weight = 295 kDa] and Lenzites sp. (a mushroom) [molecular weight = 184 kDa] were found to possess high cytotoxic activity against the test organisms. These results indicate that lectins may be further exploited as potential chemotherapeutics against certain parasitic diseases.
Bibliography:http://www.scialert.net/pdfs/jms/2005/31-34.pdf
http://www.doaj.org/doaj?func=openurl&genre=article&issn=16824474&date=2005&volume=5&issue=1&spage=31