2,3-dihydro- 1,4-benyodioxin-5-yl-piperazine derivatives having 5-HT1a -antagonistic activity

The present invention is concerned with compounds having 5-HT1A antagonistic activity useful in treating CNS disorders and having formula 2 wherein R1 is halogen, lower alkyl or alkoxy, hydroxy, trifluotomethyl or cyano, m has the value 1 or 2 and n has the value 0 or 1, A represents an alkylene cha...

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Bibliographic Details
Main Authors JOHANNES MOS, BARTHOLOMEUS JOHANNES VAN STEEN, JAN HARTOG, JACQUES SCHIPPER
Format Patent
LanguageEnglish
Published 20.02.1995
Edition6
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention is concerned with compounds having 5-HT1A antagonistic activity useful in treating CNS disorders and having formula 2 wherein R1 is halogen, lower alkyl or alkoxy, hydroxy, trifluotomethyl or cyano, m has the value 1 or 2 and n has the value 0 or 1, A represents an alkylene chain containing 2-6 C-atoms which may be substituted with one or more lower alkyl groups or a monocyclic (hetero)aryl group, and B is methylene, ethylene, carbonyl, sulfinyl, sulfonyl or sulfur, and salts thereof.
Bibliography:Application Number: ZA19940004787