Pharmaceutical compositions containing nonionic surfactants

Pharmaceutical compositions comprise an enzymatically labile pharmaceutically active agent which is permeable through the intestinal wall or requires an intestinal permeability enhancer to permeate the intestinal wall, and at least one nonionic surfactant which is capable of protecting said active a...

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Bibliographic Details
Main Authors MICHAEL J GUMKOWSKI, WILLIAM J CURATOLO, JULIAN B LO
Format Patent
LanguageEnglish
Published 30.03.1995
Edition6
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Pharmaceutical compositions comprise an enzymatically labile pharmaceutically active agent which is permeable through the intestinal wall or requires an intestinal permeability enhancer to permeate the intestinal wall, and at least one nonionic surfactant which is capable of protecting said active agent against deactivation by enzymes. A method for the inhibition of the degradation of an enzymatically labile pharmaceutically active agent by gastrointestinal enzymes comprises combining said agent with a nonionic surfactant.
Bibliography:Application Number: ZA19930007268