Enzymatically inactive phospholipase D of corynebacterium pseudotuberculosis

A mutant Corynebacterium pseudotuberculosis phospholipase D product which is enzymatically-inactive and which exhibits the immunogenicity of phospholipase D. A vaccine composition comprising the mutant phospholipase D product is used against caseous lymphadenitis in sheep. Nucleotide and amino acid...

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Bibliographic Details
Main Authors IAN THOMAS NISBET, JILL ANNE HAYNES, JOSEPHINE TKALCEVIC
Format Patent
LanguageEnglish
Published 24.05.1993
Edition5
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
DERIVATIVES THEREOF
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
SUGARS
VINEGAR
WINE
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Summary:A mutant Corynebacterium pseudotuberculosis phospholipase D product which is enzymatically-inactive and which exhibits the immunogenicity of phospholipase D. A vaccine composition comprising the mutant phospholipase D product is used against caseous lymphadenitis in sheep. Nucleotide and amino acid sequences of the mutant phospholipase D product are disclosed, and a method of production by expression of the mutant gene. A live vaccine composition for in vivo expression of the mutant gene is also disclosed. 920921,jmsspe.001,PLD,15
Bibliography:Application Number: ZA19920007228