NOVEL BENZOCYCLOALKENECARBOXYLIC ACID AND PROCESS FOR ITS PREPARATION

PCT No. PCT/CH91/00064 Sec. 371 Date Nov. 20, 1991 Sec. 102(e) Date Nov. 20, 1991 PCT Filed Mar. 19, 1991 PCT Pub. No. WO91/14671 PCT Pub. Date Oct. 3, 1991.The novel (S)-4-(2-bromobenzoyl)-5-hydroxy-benzocyclobutene-1-carboxylic i.e. the compound of the formula (I) in free form or in salt form, can...

Full description

Saved in:
Bibliographic Details
Main Authors ANDREAS VON SPRECHER, HANSJUERG WETTER
Format Patent
LanguageEnglish
Published 27.11.1991
Edition5
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

More Information
Summary:PCT No. PCT/CH91/00064 Sec. 371 Date Nov. 20, 1991 Sec. 102(e) Date Nov. 20, 1991 PCT Filed Mar. 19, 1991 PCT Pub. No. WO91/14671 PCT Pub. Date Oct. 3, 1991.The novel (S)-4-(2-bromobenzoyl)-5-hydroxy-benzocyclobutene-1-carboxylic i.e. the compound of the formula (I) in free form or in salt form, can be used as active ingredient in pharmaceutical preparations and can be prepared by a novel process, which is characterized in that racemic 4-(2-bromobenzoyl)-5-hydroxy-benzocyclobutene-1-carboxylic acid is reacted at elevated temperature with at least the equimolar amount of quinine in an alcoholic solvent for from approximately 6 to approximately 48 hours, the quinine salt of the (S)-4-(2-bromobenzoyl)-5-hydroxy-benzocyclobutene-1-carboxylic acid, precipitated in crystalline form as the direct reaction product, is separated from the reaction mixture, and the (S)-4-(2-bromobenzoyl)-5-hydroxy-benzocyclobutene-1-carboxylic acid is set free from this salt by acid treatment in a customary manner, and, if desired, this free acid is converted into a salt.
Bibliography:Application Number: ZA19910002262