1,1-DIPHENYL-PROPANOL DERIVATIVES,PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

• Main Authors: TOERLEY JOZSEF, HAJDU ISTVAN, SZPORNY LASZLO, GOEROEG SANDOR, TOTH EDIT, SZEBERENYI SZABOLCS, PALOSI EVA
• Format: Patent
• Language: English
• Published: 29.08.1984
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to new 1,1-diphenylpropan-1-ol derivatives of the formula (I)whereinR, and R2 independently represent hydrogen, halogen, trihalomethyl, alkyl having from one to 4 carbon atoms or alkoxy having from one to 4 carbon atoms,R3 is halogen, trihalomethyl, alkyl having from one to 5 carbon atoms or alkoxy having from one to 5 carbon atoms,R4 is phenyl optionally substituted by one or more identical or different substituents selected from the group of halogen, trihalomethyl, alkyl, alkoxy, cyano, nitro, amino, alkylamino, dialkylamino, hydroxyl, carboxyl or substituted carboxyl; dialkylaminocarbonyl or alkoxycarbonyl containing from one to 4 carbon atoms in the alkyl and alkoxy moieties, respectively,n is 1, 2, 3, 4 or 5.According to another aspect of the invention there are provided processes for the preparation of the compound of formula (I).The new compounds stimulate the polysubstrate mono- oxygenase enzyme of the liver in comparison with reference compounds. Pharmaceutical compositions containing compounds of the formula (I) as active ingredient are also within the scope of the invention.