PROCESS FOR THE PREPARATION OF APOVINCAMINIC ACID ESTERS

A process is disclosed for the preparation of racemic cis or trans apovincaminic acid esters of the formula (I) (I) and the corresponding optically active derivatives of the formulae (Ia) (Ia) and/or (Ib) (Ib) and/or (Ic) (Ic) and/or (Id) (Id) wherein R1 and R2 are identical or different alkyl group...

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Bibliographic Details
Main Authors SZABO LAJOS, VISKY GYOERGY, FARKAS MARIA, SZANTAY CSABA, KREIDL JANOS, KALAUS GYOERGY, CZIBULA LASZLO, NEMES ANDRAS
Format Patent
LanguageEnglish
Published 25.05.1983
Edition3
Subjects
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:A process is disclosed for the preparation of racemic cis or trans apovincaminic acid esters of the formula (I) (I) and the corresponding optically active derivatives of the formulae (Ia) (Ia) and/or (Ib) (Ib) and/or (Ic) (Ic) and/or (Id) (Id) wherein R1 and R2 are identical or different alkyl groups having 1 to 6 carbon atoms. Apovincaminic acid alkyl esters are well-known vasodilating compounds.
Bibliography:Application Number: ZA19820003873