PROCESS FOR THE PREPARATION OF APOVINCAMINIC ACID ESTERS

Apovincaminic acid esters of the general formula (I> (wherein R and R independently represent alkyl groups having from 1 to 6 carbon atoms) may be prepared by reacting a hydroxyamino-E-homo- eburnane of the general formula (II> (wherein R and R are as defined above) or an acid addition salt th...

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Main Authors SZABO LAJOS, VISKY GYOERGY, FARKAS MARIA, SZANTAY CSABA, KREIDL JANOS, KALAUS GYOERGY, CZIBULA LASZLO, NEMES ANDRAS
Format Patent
LanguageEnglish
Published 30.03.1983
Edition3
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Apovincaminic acid esters of the general formula (I> (wherein R and R independently represent alkyl groups having from 1 to 6 carbon atoms) may be prepared by reacting a hydroxyamino-E-homo- eburnane of the general formula (II> (wherein R and R are as defined above) or an acid addition salt thereof with an organic sulfonic acid, in an aprotic organic solvent. The compounds of the general formula (I) are useful pharmaceuticals.
Bibliography:Application Number: ZA19810006100