INSULIN CRYSTAL SUSPENSION AND PROCESS FOR THE PREPARATION THEREOF

1. A process for the structural transformation of rhombohedrally crystallized insulin, preferably of pig origin, having a 4-Zn structure to rhombohedrons having a 2-Zn structure, which comprises maintaining the crystals having a 4-Zn structure in an aqueous medium containing less than 6% of sodium c...

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Bibliographic Details
Main Author THUROW H
Format Patent
LanguageEnglish
Published 26.08.1981
Edition3
Subjects
CHEMISTRY
COMPOUNDS OF UNKNOWN CONSTITUTION
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PERFORMING OPERATIONS
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SEPARATION
TRANSPORTING
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Summary:1. A process for the structural transformation of rhombohedrally crystallized insulin, preferably of pig origin, having a 4-Zn structure to rhombohedrons having a 2-Zn structure, which comprises maintaining the crystals having a 4-Zn structure in an aqueous medium containing less than 6% of sodium chloride, the pH of which medium is adjusted to 4.5 to 6.0 and maintained stable by addition of a buffer, at a temperature ranging from room temperature to 45 degrees C until in a sample crystals of the 4-Zn structure are no longer present.
Bibliography:Application Number: ZA19800005152