SUBSTITUTED TRICYCLIC COMPOUNDS

Disclosed are compounds of the general formula (I), its tautomeric form, its stereoisomer, its pharmaceutically acceptable salt, its polymorph, or solvate thereof, wherein, ring A, ring B, R1 to R4, and n are as defined herein, for use as SOS1 inhibitors in the treatment of proliferative, infectious...

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Main Authors PHUKAN, Samiron, NAIR, Prathap Sreedharan, PALLE, Venkata P, LIMAYE, Rohan, MAHANGARE, Sachin, KAMBOJ, Rajender Kumar, GORE, Balasaheb, WALKE, Navnath, KURHADE, Sanjay, Pralhad, PATIL, Pradeep Rangrao, MAJID, Sayyed, SETHI, Sachin, BHOSALE, Avadhut, SINDKHEDKAR, Milind Dattatraya, TAMBE, Vikas, SHUKLA, Manojkumar Ramprasad, PHADATARE, Ramesh, PACHPUTE, Vipul
Format Patent
LanguageEnglish
Published 29.03.2023
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Summary:Disclosed are compounds of the general formula (I), its tautomeric form, its stereoisomer, its pharmaceutically acceptable salt, its polymorph, or solvate thereof, wherein, ring A, ring B, R1 to R4, and n are as defined herein, for use as SOS1 inhibitors in the treatment of proliferative, infectious and RASopathy diseases or disorders. Also disclosed are methods of synthesizing the compound of formula I, pharmaceutical compositions containing the compound of formula I, method of treatment of proliferative, infectious and RASopathy diseases or disorder, for example, a cancer, by administering the said compound and combinations of the compound of formula I with other active ingredients.
Bibliography:Application Number: ZA20220007722