PYRIDAZINYL-THIAZOLECARBOXAMIDE COMPOUND

• Main Authors: OSAMU IKEDA, YOHEI SEKI, YOSHINORI IWAI, KOZO MIYASAKA, HIROSHI TOMIYAMA, KAZUO KUROSAWA, HIDEYUKI WATANABE, KEIICHIRO OKUYAMA, AKIHIKO NAKAMURA
• Format: Patent
• Language: English
• Published: 20.12.2023

A compound useful as an active ingredient of a pharmaceutical composition for treatment of cancer related to activation of immune cells or cancer having resistance to anti-PD-1 antibody / anti-PD-Ll antibody therapy is provided.The present inventors have conducted studies on a compound useful as an active ingredient of a pharmaceutical composition for treatment of cancer related to activation of immune cells or cancer having resistance to anti-PD-1 antibody / anti-PD-Ll antibody therapy, and found that a pyridazinyl-thiazolecarboxamide compound has DGK ξ (DGKzeta) inhibitory effect, leading to completion of the present invention. The pyridazinyl-thiazolecarboxamide compound of the present invention has DGK ξ inhibitory effect, and can be used as a therapeutic agent for treatment of cancer related to activation of immune cells or cancer having resistance to anti-PD-1 antibody / anti-PD-Ll antibody therapy.