QUINAZOLIN-4-ONE DERIVATIVES USEFUL FOR THE TREATMENT OF BRAF-ASSOCIATED DISEASES AND DISORDERS

Provided herein are compounds of the formula I: and pharmaceutically acceptable salts, solvates and polymorphs thereof, wherein L, X1, R1, R2, R3, R4, R5 and R6 are as defined herein, for the treatment of BRAF-associated diseases and disorders, including BRAF-associated tumors, including malignant a...

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Main Authors METCALF, Andrew Terrance, TARLTON, Eugene, LAIRD, Ellen Ruth, BROWN, Katie Keaton, BARBOUR, Patrick Michael, MORENO, David Austin, PRIGARO, Brett Joseph, PAJK, Spencer Phillip, NEWHOUSE, Bradley Jon, HICKEN, Erik James, REN, Li, COOK, Adam Wade, KAHN, Dean Russell
Format Patent
LanguageEnglish
Published 27.09.2023
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Summary:Provided herein are compounds of the formula I: and pharmaceutically acceptable salts, solvates and polymorphs thereof, wherein L, X1, R1, R2, R3, R4, R5 and R6 are as defined herein, for the treatment of BRAF-associated diseases and disorders, including BRAF-associated tumors, including malignant and benign BRAF-associated tumors of the CNS and malignant extracranial BRAF-associated tumors.
Bibliography:Application Number: ZA20220001329