2-AMINO-N-HETEROARYL-NICOTINAMIDES AS NAV1.8 INHIBITORS

Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of Nav1.8 channel activity and may be useful in the treatment, prevention, management, amelioration, control and suppression of diseases mediated by Nav1.8 channel activity. The compounds...

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Main Authors CHOBANIAN, Harry R, BELL, Ian M, BURGEY, Christopher S, SUEN-LAI, Linda M, PERKINS, James J, JONES, Kristen L. G, COX, Jason M, BRESLIN, Michael J, LIU, Jian, ARASAPPAN, Ashok, WU, Zhe, STACHEL, Shawn J, GINNETTI, ANTHONY T, LAYTON, Mark E, GUIADEEN, Deodial Guy, LIU, Hong, BUNGARD, Christopher James
Format Patent
LanguageEnglish
Published 25.10.2023
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Summary:Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of Nav1.8 channel activity and may be useful in the treatment, prevention, management, amelioration, control and suppression of diseases mediated by Nav1.8 channel activity. The compounds of the present invention may be useful in the treatment, prevention or management of pain disorders, cough disorders, acute itch disorders, and chronic itch disorders.
Bibliography:Application Number: ZA20210002628