TRISPECIFIC AND/OR TRIVALENT BINDING PROTEINS

The disclosure provides trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more target proteins, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a c...

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Main Authors LANGE, Christian, NABEL, Gary, J, BEIL, Christian, SEUNG, Edward, RAO, Ercole, YANG, Zhi-Yong, WU, Lan, CORVEY, Carsten, BENINGA, Jochen, LEUSCHNER, Wulf Dirk, WEI, Ronnie
Format Patent
LanguageEnglish
Published 26.01.2022
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Summary:The disclosure provides trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more target proteins, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation and wherein a second pair of polypeptides forming the binding protein possess a single variable domain. The disclosure also provides methods for making trispecific and/or trivalent binding proteins and uses of such binding proteins.
Bibliography:Application Number: ZA20200006103