TRICYCLIC COMPOUNDS AS HISTONE METHYL-TRANSFERASE INHIBITORS
The present disclosure provides certain tricyclic compounds that are histone methyltransferases G9a and/or GLP inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of G9a and/or GLP such as cancers and hemoglobinopathies (e.g., beta-thalassemia and sickle cell di...
Saved in:
| Main Authors | , , , |
|---|---|
| Format | Patent |
| Language | English |
| Published |
26.07.2023
|
| Online Access | Get full text |
Cover
Loading…
| Abstract | The present disclosure provides certain tricyclic compounds that are histone methyltransferases G9a and/or GLP inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of G9a and/or GLP such as cancers and hemoglobinopathies (e.g., beta-thalassemia and sickle cell disease). Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds. |
|---|---|
| AbstractList | The present disclosure provides certain tricyclic compounds that are histone methyltransferases G9a and/or GLP inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of G9a and/or GLP such as cancers and hemoglobinopathies (e.g., beta-thalassemia and sickle cell disease). Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds. |
| Author | LI, Zhe YU, Ming XU, Qing ZANCANELLA, Manuel |
| Author_xml | – fullname: ZANCANELLA, Manuel – fullname: XU, Qing – fullname: YU, Ming – fullname: LI, Zhe |
| BookMark | eNrjYmDJy89L5WSwCQnydI509vF0VnD29w3wD_VzCVZwDFbw8AwO8fdzVfB1DfGI9NENCXL0C3ZzDXIMdlXw9PPwdPIM8Q8K5mFgTUvMKU7lhdLcDIpuriHOHrqpBfnxqcUFicmpeakl8VGORgZGBgaGpgbGTsbEqAEARtErtg |
| ContentType | Patent |
| DBID | EVB |
| DatabaseName | esp@cenet |
| DatabaseTitleList | |
| Database_xml | – sequence: 1 dbid: EVB name: esp@cenet url: http://worldwide.espacenet.com/singleLineSearch?locale=en_EP sourceTypes: Open Access Repository |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Chemistry Sciences |
| ExternalDocumentID | ZA202001503B |
| GroupedDBID | EVB |
| ID | FETCH-epo_espacenet_ZA202001503B3 |
| IEDL.DBID | EVB |
| IngestDate | Fri Jul 19 12:45:42 EDT 2024 |
| IsOpenAccess | true |
| IsPeerReviewed | false |
| IsScholarly | false |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-epo_espacenet_ZA202001503B3 |
| Notes | Application Number: ZA20200001503 |
| OpenAccessLink | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230726&DB=EPODOC&CC=ZA&NR=202001503B |
| ParticipantIDs | epo_espacenet_ZA202001503B |
| PublicationCentury | 2000 |
| PublicationDate | 20230726 |
| PublicationDateYYYYMMDD | 2023-07-26 |
| PublicationDate_xml | – month: 07 year: 2023 text: 20230726 day: 26 |
| PublicationDecade | 2020 |
| PublicationYear | 2023 |
| RelatedCompanies | Global Blood Therapeutics, Inc |
| RelatedCompanies_xml | – name: Global Blood Therapeutics, Inc |
| Score | 3.4795394 |
| Snippet | The present disclosure provides certain tricyclic compounds that are histone methyltransferases G9a and/or GLP inhibitors and are therefore useful for the... |
| SourceID | epo |
| SourceType | Open Access Repository |
| Title | TRICYCLIC COMPOUNDS AS HISTONE METHYL-TRANSFERASE INHIBITORS |
| URI | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230726&DB=EPODOC&locale=&CC=ZA&NR=202001503B |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3dS8MwED_mFPVNpzLnBxWkb0VZu9SCQ9o0pZW1HW0n215G00XQh264iv--17A5X_QtJHDcHdxHLne_ANxizj0vekRolqlzzUDfqHGSzzVuCQxwD8IyJG5BGBF_ZDyPe-MGvG9mYSRO6JcER0SLKtDeK-mvl9silit7K1d3_A23Fk9e1nfV9e247mruEtV1-mwYuzFVKe1PbTVK6jOJpqc7O7CLabRZWwN7ceqplOXvkOIdwd4QqZXVMTRE2YIDuvl5rQX74frBG5dr21udwGOWBHRCBwFVaBwO41HkpoqdKn6QZnHElJBl_mSgZYkdpR5L7JQpQeQHTpDFSXoKNx7LqK8hG7MfmWdTe8uxfgbNclGKNiiCFKjP_NUqMLZynVhmj3AUBl3WvWHm-Tl0_qbT-e_wAg5r_dVlyy65hGb18SmuMN5W_Foq6hsqjX3P |
| link.rule.ids | 230,309,783,888,25576,76876 |
| linkProvider | European Patent Office |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LS8NAEB5qFetNq6L1FUFyC0qTbgxYJNkkZDWPkmyl7aUk6Qp6SIuN-PedhNZ60duyC8PswDx35luAG4y5Z3mPCMXQ1UzR0DYqGUlnSmYIdHD3wtBq3IIgJN5Qexr1Rg14X8_C1DihXzU4ImpUjvpe1vZ6sSli2XVv5fI2e8Ot-aPL-7a8yo6rruYukW2r7wwiO6Iypf2JKYdxdVaj6anWFmxjiK1X2uC8WNVUyuK3S3H3YWeA1IryABqiaEOLrn9ea8NusHrwxuVK95aH8MBjRsfUZ1SiUTCIhqGdSGYieSzhUehIgcO9sa_w2AwT14nNxJFY6DGL8ShOjuDadTj1FGRj-nPn6cTccKweQ7OYF-IEJEFylGf6auToWzOVGHqPZJgyoMm60_Q0PYXO33Q6_x1eQcvjgT_1Wfh8BnuVLKsSZpecQ7P8-BQX6HvL7LIW2jc8UoDC |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Apatent&rft.title=TRICYCLIC+COMPOUNDS+AS+HISTONE+METHYL-TRANSFERASE+INHIBITORS&rft.inventor=ZANCANELLA%2C+Manuel&rft.inventor=XU%2C+Qing&rft.inventor=YU%2C+Ming&rft.inventor=LI%2C+Zhe&rft.date=2023-07-26&rft.externalDBID=B&rft.externalDocID=ZA202001503B |