TRICYCLIC COMPOUNDS AS HISTONE METHYL-TRANSFERASE INHIBITORS

The present disclosure provides certain tricyclic compounds that are histone methyltransferases G9a and/or GLP inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of G9a and/or GLP such as cancers and hemoglobinopathies (e.g., beta-thalassemia and sickle cell di...

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Bibliographic Details
Main Authors ZANCANELLA, Manuel, XU, Qing, YU, Ming, LI, Zhe
Format Patent
LanguageEnglish
Published 26.07.2023
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Summary:The present disclosure provides certain tricyclic compounds that are histone methyltransferases G9a and/or GLP inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of G9a and/or GLP such as cancers and hemoglobinopathies (e.g., beta-thalassemia and sickle cell disease). Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.
Bibliography:Application Number: ZA20200001503